A Review about Dendrimers: Synthesis, Types, Characterization and Applications

This review provides brief information concerning with the dendrimer, its synthesis, characterization and application in drug delivery. Dendrimer consist of well defined size, shape, molecular weight and monodispersity. These properties formulate the dendrimers a suitable carrier in drug delivery application. Dendrimer are built from number of molecular entities of colloidal paticles that exists in equilibrium with the molecules or ions in nature and due to this increases the solubility of poorly soluble drugs. Due to their distinct structural design these have improved physical and chemical properties. The compatibility between DNA, heparin and polyanions make them more versatile. Self assembly of molecules produces a quicker means of producing nanoscopic functional and structural systems. But the genuine effectiveness in drug delivery can be assessed only after accepting their behavior in vivo. Studies have explored the biological possiblities of dendrimers such as to transportation of genes, development of vaccines, antiviral, antibacterial and anticancer therapies. This review also describes how the dendrimer interrelate with numerous drugs and the prospective of these macromolecules in addition with the drug nanocarriers in transdermal route of administration, ocular, respiratory, oral and intravenous administration. Dendrimers assure superior prospect protrusion for the biomedicine. This review provides a brief discussion of dendrimers' physico-chemical properties and their potential use in a range of areas of research, technology and treatment.